| RESEARCH PAPER
|Year : 1983 | Volume
| Issue : 2 | Page : 107-110
Response of the goat trachea to some autonomic drugs
S Kulshrestha, SS Misra, AL Sharma, P Sharma, D Singhal
Goat isolated trachea contracted to acetylcholine, histamine and barium chloride in a dose-dependent manner and to 5-hydroxytryptamine in a narrow dose range. Pheniramine blocked contractions to histamine while cimetidine potentiated. Atropine and cyproheptadine antagonised the contractions of acetylcholine and 5-hydroxytryptamine respectively. The relaxatory responses to epinephrine and isoprenaline were blocked by propranolol.
These observations suggest the presence of both H1-excitatory and H2-inhibitory receptors for histamine, excitatory tryptamine and muscarinic receptors for 5-hydroxytryptamine and atropine and á-adrenergic receptors.
Source of Support: None, Conflict of Interest: None