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Year : 1983  |  Volume : 15  |  Issue : 2  |  Page : 107-110

Response of the goat trachea to some autonomic drugs

Correspondence Address:
S Kulshrestha

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Source of Support: None, Conflict of Interest: None

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Goat isolated trachea contracted to acetylcholine, histamine and barium chloride in a dose-dependent manner and to 5-hydroxytryptamine in a narrow dose range. Pheniramine blocked contractions to histamine while cimetidine potentiated. Atropine and cyproheptadine antagonised the contractions of acetylcholine and 5-hydroxytryptamine respectively. The relaxatory responses to epinephrine and isoprenaline were blocked by propranolol. These observations suggest the presence of both H1-excitatory and H2-inhibitory receptors for histamine, excitatory tryptamine and muscarinic receptors for 5-hydroxytryptamine and atropine and á-adrenergic receptors.


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