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Year : 1982  |  Volume : 14  |  Issue : 4  |  Page : 345-350

Preliminary observation regarding the cataleptogenic activity of maprotiline in the mouse

Correspondence Address:
J J Balsara

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Source of Support: None, Conflict of Interest: None

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Maprotiline (5-40 mg/kg ip) was found to induce catalepsy in mice. Treatment with apomorphine (2.5 and 5 mg/kg. ip) and atropine (20 mg/kg, ip) significantly reduced the cataleptic effect of maprotiline. Further, pretreatment with maprotiline (2.5-10 mg/kg, ip) significantly antagonised apomorphine-induced cage climbing behaviour in mice. The results suggest that the cataleptogenic effect of maprotiline is probably due to blockade of post-synaptic striatal dopamine receptors.


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