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Year : 1982  |  Volume : 14  |  Issue : 4  |  Page : 341-344

Effect of baclofen pretreatment on pentobarbitone sleep in mice

Correspondence Address:
V V Joshi

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Source of Support: None, Conflict of Interest: None

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Pretreatment with baclofen, the p-chlorophenyl analogue of GABA, not only prolonged pentobarbitone sleeping time but also induced sleep in mice treated with a subhypnotic dose of pentobarbitone.Probable mechanism involved in the potentiating effect of baclofen on pentobarbitone hypnosis has been discussed on the basis that baclofen by inhibiting the firing of DAergic neurons decreases the activity of the nigrostriatal and mesolimbic DAergic systems involved in cortical activation and behavioural arousal and thus sensitizes the CNS to the depressant action of pentobarbitone. Further, our finding that the subconvulsant dose of picrotoxin, a GABA antagonist, failed to antagonise the potentiating effect of baclofen pretreatment on pentobarbitone hypnosis is in agreement with the report that picrotoxin fails to antagonise the action of baclofen on the DAergic neurons.


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