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Year : 1982  |  Volume : 14  |  Issue : 4  |  Page : 325-332

Effect of baclofen pretreatment on the antinociceptive and cataleptic effect of morphine in mice

Correspondence Address:
J J Balsara

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Source of Support: None, Conflict of Interest: None

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Baclofen, the p-chlorophenyl analog of GABA, was found to exert antinociceptive activity and to induce catalepsy in mice. -Further pretreatment with sub-analgesic and sub cataleptic doses of baclofen was found to potentiate morphine-induced analgesia and catalepsy respectively. The possible mechanism involved in the induction of analgesia and catalepsy and in the potentiation of morphine-induced analgesia and catalepsy by baclofen is discussed on the basis of the inhibitory action of baclofen on the firing of the nigro-neostriatal dopaminergic neurons, which have been implicated in the control of nociceptive reflex activity and in the action of analgesic agents and whose hypofunctioning results in catalepsy.


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