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Year : 1982  |  Volume : 14  |  Issue : 4  |  Page : 313-318

Studies on autonomic actions of levamisole and phenylephrine in rat anococcygeus and frog’s isolated heart

Correspondence Address:
D P Joshi

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Source of Support: None, Conflict of Interest: None

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Levamisole. a broad spectrum anthelmintic and phenylephrine, an alpha-receptor stimulant, were studied on anococcygeus muscle of rat (RA) and isolated heart of frog. In RA, levamisole and phenylephrine both produces dose dependent contractions which were blocked by phentolamine, but not by practolol. a (-receptor blocker. Phenylephrine was more potent than levamisole in (-receptor stimulating activity. In isolated frog's heart, levamisole produced dose dependent negative inotropic effects. At higher doses it produced a complete cardiac arrest in diastole. The cardiac, inhibitory effects of levamisole are, not altered by atropine. Our results suggest that levamisole and phenylephrine both produces contractions in RA through stimulation of alpha-adrenoceptors. Inhibitory effects of levamisole on frog's cardiac muscles may be direct.


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