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Year : 1982  |  Volume : 14  |  Issue : 4  |  Page : 309-312

Metoclopramide in tardive dyskinesia

Correspondence Address:
T J Hemnani

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Source of Support: None, Conflict of Interest: None

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The effect of single intravenous doses of metoclopramide ( 10 mg, 20 mg and 40 mg) have been compared with placebo (saline) in a double blind randomised study in 10 patients with tardive dyskinesia, following long term neurokptic therapy. Tardive dyskinesia rating scores were decreased significantly 6 h after administration of meloclopramide (20 mg and 40 mg), when compared with placebo. Reduction of tardive dyskinasia by metoclopramide. ,aD2 receptor- blocking agent, suggest that D2 receptors may be involved in the mediation of this syndrome.


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