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Year : 1982  |  Volume : 14  |  Issue : 4  |  Page : 305-308

In vitro hemolytic property of substituted phenothiazines

Correspondence Address:
A K Khasnobis

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Source of Support: None, Conflict of Interest: None

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In vitro hemolytic property of four commonly used substituted phenothiazine derivatives were studied on rabbit's washed erythrocytes, in isotonic saline. substitution of SCH2 group in place of H in position 2 of the phenothiazine ring, markedly increased the hemolytic activity, when compared with CF3 or Cl- substitution in the same position. Hemolytic property of these compounds also increased with the increase of incubation time and temperature.


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