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Year : 1982  |  Volume : 14  |  Issue : 4  |  Page : 301-304

Modification of glibenclamide hypoglycaemia by some antihypertensive agents in rabbits

Correspondence Address:
H Mishra

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Chlorthalidone (3.0 mg/kg), hydrochlorthiazide (3.0 mg/kg), frusemide (1.0 mg/kg) and clonidine (0.003 mg/kg) did not have any per se effect on fasting blood sugar level of rabbits upto 5 h. when clonidine was administered along with glibenclamide (0.025 mg/k), it not only caused an early onsent of hypo- glycaema but also produced greater fall in blood sugar than that observed with glibenclamide alone. The diuretics did not modify the hypoglycaemic activity of glibenclamide.


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