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Year : 1982  |  Volume : 14  |  Issue : 3  |  Page : 277-280

Modification of glibenclamide hypoglycaemia by some antihypertensive agents in rabbits

Correspondence Address:
H Mishra

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Source of Support: None, Conflict of Interest: None

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Chlorthalidone ( 3.0 mg.kg, ), hydrochlorthiazide ( 3.0 mg/kg ), frusemide (1 .0 mg/kg) and clonidine (0.003 mg/kg) did not have any per se effect on fasting blood sugar level of rabbits up to 5 h.When clonidine was administered along with glibenclamide (0.024 mg/kg), it not only caused early onset of hypoglycaemia but also Produced greater fall in blood sugar than observed with glibenclamide alone. The diuretics did not modify the hypoglycaemic activity of glibenclamide.


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