| SHORT COMMUNICATION
|Year : 1982 | Volume
| Issue : 3 | Page : 277-280
Modification of glibenclamide hypoglycaemia by some antihypertensive agents in rabbits
H Mishra, B Gupta, KK Saxena, VK Kulshrestha, DN Prasad
Chlorthalidone ( 3.0 mg.kg, ), hydrochlorthiazide ( 3.0 mg/kg ), frusemide (1 .0 mg/kg) and clonidine (0.003 mg/kg) did not have any per se effect on fasting blood sugar level of rabbits up to 5 h.When clonidine was administered along with glibenclamide (0.024 mg/kg), it not only caused early onset of hypoglycaemia but also Produced greater fall in blood sugar than observed with glibenclamide alone. The diuretics did not modify the hypoglycaemic activity of glibenclamide.
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