| SHORT COMMUNICATION |
|
| Year : 1982 | Volume
: 14
| Issue : 3 | Page : 273-276 |
Anti-inflammatory, anticonvulsant and local anaesthetic activity of clonidine – A preliminary report
P Jain, VK Pendse, KP Singh, SD Suthar
Correspondence Address:
P Jain
 Source of Support: None, Conflict of Interest: None  | Check |
Clonidine, a potent centrally acting antihypertensive drug was screened for anti-inflammatory, anticonvulsant and local anaesthetic activity. In carrageenin-induced inflammation it showed a significant dose dependent anti-inflammatory effect. Clonidine failed to show any anticonvulsant effect against maximal electro-shock convulsions in rats, however it exhibited significant local anaesthetic activity. Diuresis, piloerection and convulsions were observed in higher doses.
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