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Year : 1982  |  Volume : 14  |  Issue : 3  |  Page : 273-276

Anti-inflammatory, anticonvulsant and local anaesthetic activity of clonidine – A preliminary report

Correspondence Address:
P Jain

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Source of Support: None, Conflict of Interest: None

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Clonidine, a potent centrally acting antihypertensive drug was screened for anti-inflammatory, anticonvulsant and local anaesthetic activity. In carrageenin-induced inflammation it showed a significant dose dependent anti-inflammatory effect. Clonidine failed to show any anticonvulsant effect against maximal electro-shock convulsions in rats, however it exhibited significant local anaesthetic activity. Diuresis, piloerection and convulsions were observed in higher doses.


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