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Year : 1982  |  Volume : 14  |  Issue : 3  |  Page : 247-258

Effect of maternal administration of acetaldehyde on fetal development in the rat

Correspondence Address:
R Padmanabhan

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Source of Support: None, Conflict of Interest: None

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The teratogenicity of acetaldehyde, the proximal metabolite of ethanol and an industrial pollutant, has been studied in CF rats following intravenous administration (75 and 200 mg/Kg) from day 8 to 15 of gestation (sperm positive day = day 1). Besides dose dependent lethality, fetuses collected at term were significantly stunted as assessed by somatometric measurements and alizarin stained skeletal preparations. The malformations observed included microcephaly, micrognathia. micromelia, digital anomalies and edema. The close resemblance of the spectrum of malformations to that associated with fetal alcohol syndrome (FAS) is suggestive of the possible implication of acetaldehyde in. FAS:


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