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Year : 1982  |  Volume : 14  |  Issue : 2  |  Page : 191-199

A study of anticonvulsant activity of N-substituted derivatives of 1-anilinocycloxane-1-amide

Correspondence Address:
S N Mukhopadhyay

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Source of Support: None, Conflict of Interest: None

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Eleven N-substituted derivatives of l-anilinocyclohexane-l-amide and l-p -anisidino cyclohexane-I-amide with different side chains viz. dimethylamino, di-n-butylamino, dibenzylamino, piperidino, pyrrolidino and morpholino moieties were synthesised using Mannich reaction. Anticonvulsant activity of these compounds was studied against electroshock and metrazol seizures in albino rats and against strychnine convulsions in frogs. Out of the eleven test compounds, significant protection was observed with six compounds against electroshock seizures and with eight compounds against metrazol seizures. Dibenzylamino and morpholino derivatives of both 1-anilino and 1-p-anisidino moieties showed protection against electroshock and metrazol induced convulsions. None of the test compounds antagonised strychnine convulsions in frogs. Most of the compounds that showed anticonvulsant activity produced sedation and potentiated pentobarbitone hypnosis in albino rats.


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