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Year : 1982  |  Volume : 14  |  Issue : 2  |  Page : 183-190

Behavioural interactions of metoclopramide

Correspondence Address:
T J Hemnani

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Source of Support: None, Conflict of Interest: None

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Metoclopramide is devoid of significant antipsychotic action, but it may exhibit this property in combination with tolazoline, propranolol, phenobarbitone, diphenylhydantoin and mepyramine. The antipsychotic action is dose dependent on metoclopramide but the sufficient quantity of an adjuvant drug is required for triggering this action. This antipsychotic action is seen in much lower doses which do not inhibit unconditioned responses as well as forced locomotor activity. In addition metoclopramide antagonises the antipsychotic action of reserpine and haloperidol in a competitive manner, while the action of chlorpromazine is unaffected.


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