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Year : 1982  |  Volume : 14  |  Issue : 2  |  Page : 163-168

Kinetics of lithium in normal volunteers

Correspondence Address:
C B Khare

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Source of Support: None, Conflict of Interest: None

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Six normal volunteers completed the study following oral administration of conventional and later slow release preparation of lithium carbonate. Mean serum levels over 24 h were calculated. The average time required to reach maximum concentration in serum was 5 h in conventional form and 6 h in case of slow release form. The maximum concentration did not differ significantly. The bio-availability of the conventional form was 79.9% of the slow release form. The volume of distribution and metabolic clearance rates for both the forms were similar. Implications of these findings are discussed.


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