IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 3430 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded77    
    Comments [Add]    

Recommend this journal


Year : 1982  |  Volume : 14  |  Issue : 2  |  Page : 143-148

The effect of adrenoceptor blockers (propranolol and phenoxybenzamine) on single – trial passive avoidance response in rats

Correspondence Address:
N Jagdev

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

Rats received a single training trial on a n inhibitory avoidance (passive avoidance) rats, and retention trials 24 h (R-I) and 48 h (R-II) later.The animals were subjected to 5 different trial, scheduld(s) : control, pre-trial, pre-trial plus pre-retention, pre-retention, and post-trial in a special two chambered apparatus, and the step-through latency was determined. Propranolol (6.5 mg/kg ip) increased the mean 'step-through latencies significantly in groups III & IV (P < 0.05 and group II & V (P<0.001) as compared to that in group I on R-I There was a similar increase in the retest lalatencies in groups II & III (P<0.01) and group IV & V(p <0.001), as compared to that is group I on R-II. Phenoxybenzamine (5.0 mg/kg ip) had an insignificant effect on the retest latenoes in all the groups both after 24 h and 48 h retention trials.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow