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Year : 1981  |  Volume : 13  |  Issue : 4  |  Page : 353-355

Comparison of pA values of three anticholinergic drugs

Correspondence Address:
M P Shrivastava

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Source of Support: None, Conflict of Interest: None

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PA2 and PA10 value of three. anticholinergic drugs i. e. atropine, oxyphenonium and diphenhydramine have been estimated on three isolated tissues of guineapig i. e. ileum, urinary bladder and vas deferens. The difference between pA2 and pA10 has been chosen as the criteria to establish the type of antagonism in different tissues with different drugs Antagonism seems to be of competitive nature in all tissues except Vas deferens with atropine.


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