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Year : 1981  |  Volume : 13  |  Issue : 4  |  Page : 349-351

Mechanism of direct vasodilator effect of thiazide diuretics

Correspondence Address:
S S Rao

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Source of Support: None, Conflict of Interest: None

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The mechanism of direct vasodilator effect of thiazides was studied by using isolated strips prepared from rabbit aorta. All the thiazides caused relaxation of noradrenaline induced contraction but had no effect on the contractions produced by other smooth muscle stimulants. Thiazides per se did not block the effect of noradrenaline and their relaxant effect was not abolished by prior treatment with propranolol. It was absent in Ca2+ free Kreb's solution and was reversed by increasing the concentration of calcium. The probable mechanism of thiazide action appears to be an interferance with intracellular Ca2+ release by nor adrenaline.


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