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Year : 1981  |  Volume : 13  |  Issue : 4  |  Page : 285-292

Effect of immobilization stress on hypothalamic monoamines

Correspondence Address:
A K Sanyal

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Source of Support: None, Conflict of Interest: None

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Hypothalamic 5-hydroxytryptamine (5-HT), dopamine (DA) and noradrenaline (NA) were estimated (from the same homogenate) in male wistar albino rats after different periods of immobilisation stress (IS). The rate of accumulation of these monoamines in the hypothalamus was also estimated after tranylcypromine pretreatment. There is an significant increase in the rate of synthesis of 5 HT between 30-60 min and that of DA between 15-30 min. The rate of synthesis of 5-HT decrease between 60-120 min and that of DA between 30-120 min. The is no significant change in the metabolism of hypothalamic NA. The results of the present study corroborate the earlier reported observation that early (0-30 min) and late (30-120 min) phase of S-induced hypothermia are primarily DA and 5-HT mediated.


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