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Year : 1981  |  Volume : 13  |  Issue : 3  |  Page : 271-277

Cardiotonic activity of selective fatty acids in amphibian heart

Correspondence Address:
S B Patel

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Source of Support: None, Conflict of Interest: None

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Sodium stearate (5 x10-5M to 8x I0-4M) and sodium oleate (1 x 10-4M to 1.6 x I0-3M) exhibited positive inotropic effect on isolated frog's heart. The inotropic action to these fatty acids were blocked competitively by propronolol (1 x 10-6M), while phentolamine (1 x 10-6M) did not alter the responses to these fatty acids significantly. Imidazole (I x I0-4M) perfusion inhibited the fatty acids induced positive inotropic action, whereas caffeine (1 x l0-4M) potentiated the responses to these fatty acids. Moreover, there was decrease in responses upon repeated administration of submaximal dose of fatty acids. Our data suggests that sodium stearate and sodium oleate produced cardiotonic effect which could be through the release of catecholamince


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