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Year : 1981  |  Volume : 13  |  Issue : 3  |  Page : 261-270

Studies on the effects of adrenaline, noradrenaline and phenylephrine on the estrogen primed rat myometrium

Correspondence Address:
R K Goyal

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Source of Support: None, Conflict of Interest: None

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Adrenaline, noradrenaline and phenylephrine produed dose dependent relaxation of estrogen primed rat uterus. The responses to all three agonists were blocked competitively by propranolol (1.0x 10-6M to 1.0 x l0-7M), a specific ( receptor antagonist. Phentolamine (1.0x l0-6 M), a specific a receptor antagonist failed to inhibit these responses. The response to phenylephrine and noradrenaline were potentiated by caffeine perfusion (5.1 x l0-5M), a phosphodiesterase inhibitor, whereas imidazole perfusion (1.4x 10-4 M) inhibited the responses to phenylephrine and noradrenaline. Our data suggest specific ( receptor action of phenylephrine and noradrenaline in estrogen primed rat uterus. It is also suggestive that ( receptor action may be associated with adenylate cyclase cyclic 3'-5' adenosine monophosphate, (CAMP) system in this tissue.


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