| RESEARCH PAPER
|Year : 1981 | Volume
| Issue : 3 | Page : 261-270
Studies on the effects of adrenaline, noradrenaline and phenylephrine on the estrogen primed rat myometrium
RK Goyal, SC Verma
Adrenaline, noradrenaline and phenylephrine produed dose dependent relaxation of estrogen primed rat uterus. The responses to all three agonists were blocked competitively by propranolol (1.0x 10-6M to 1.0 x l0-7M), a specific ( receptor antagonist. Phentolamine (1.0x l0-6 M), a specific a receptor antagonist failed to inhibit these responses. The response to phenylephrine and noradrenaline were potentiated by caffeine perfusion (5.1 x l0-5M), a phosphodiesterase inhibitor, whereas imidazole perfusion (1.4x 10-4 M) inhibited the responses to phenylephrine and noradrenaline. Our data suggest specific ( receptor action of phenylephrine and noradrenaline in estrogen primed rat uterus. It is also suggestive that ( receptor action may be associated with adenylate cyclase cyclic 3'-5' adenosine monophosphate, (CAMP) system in this tissue.
R K Goyal
Source of Support: None, Conflict of Interest: None