| RESEARCH PAPER
|Year : 1981 | Volume
| Issue : 3 | Page : 245-251
Pharmacological investigation into the positive inotropic, chronotropic and hemodynamic effects of BDPU, [1-Butyl-3 (1-(6,7 dimethoxyquinzanoline 4-yl) piperidine –1-yl urea
SC Verma, LN Iyengar
BDPU [ (1-butyl-3(1,(6-7-dimethoxyquinoline-4-yl) piperidine 4-yl urea)] produced dose dependent (20 'g to 160 'g) positive inotropic effect on the isolated heart of guinea-pig. Reserpine pre-treatment (5 mg/kg., ip, 24 h) shifted the BDPU dose response curve to the 1eft. This may, be a supersensitive phenomena. In the anesthetized dog BDPU did not produce significant changes in blood pressure at doses 50, 100 and 200 'g/kg. At higher dose 400 'g/kg a fall in the mean arterial pressure was observed.Neither propranolol (l0-7M) nor phentolamine(10-7 M) produced any shift of the dose response curve of BDPU. Theophylline (l0-3M) and imidazole (20mM) perfusion did not alter BDPU responses. The positive inotropic responses of BDPU seem to be due to direct changes in calcium availability in the myocardium.
S C Verma
Source of Support: None, Conflict of Interest: None