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Year : 1981  |  Volume : 13  |  Issue : 2  |  Page : 199-201

Comparison of total alkaloids of Tylophora indica and disodium cromoglycate on mast cell stabilization

Correspondence Address:
V S Geetha

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Source of Support: None, Conflict of Interest: None

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The total alkaloids of Tylophora indica were tested for mast cell stabilising effect in comparison with disodium cromoglycate by challenging against three different mast cell degranulators, diazoxide, carbachol and polymixin B, in vitro. Both tylophora alkaloids and disodium cromoglycate prevented in similar concentrations, the mast cell degranulation occurring with diazoxide alone. Tylophora alkaloids and disodium cromoglycate did not significantly affect the carbachol and ploymyxim induced degranulation of mast cells. The results suggest that Tylophora alkaloids may have similar mechanism of action as disodium cromoglycate through cyclic AMP.


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