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Year : 1981  |  Volume : 13  |  Issue : 2  |  Page : 185-194

Structure-activity relationship of benzopyrones towards their anti autacoid and anti-acetylcholine activity

Correspondence Address:
D K Basu

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Source of Support: None, Conflict of Interest: None

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Six closely related classes ot benzopyrones have been screened for their anti-autacoid and antiacetylcholine activity on the guinea pig ileum preparation. Their effect on histamine release upon mast cell degranulaiton by compound 48/80 has also been evaluated. Chromones were found to be the most effective benzopyrones in antagonising brady-kinin, 5-HT and acetylcholine induced contractions of the guinea pig ileum as well as in inhibiting mast cell degranulation. None of the benzopyrone produced anti-histaminic activity on the ileum preparation. 2 methyl chromone substituted at position 7 and 8 by hydroxyl, alkoxyl or acetoxyl groups showed maximum activity in all the parameters studied.


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