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Year : 1981  |  Volume : 13  |  Issue : 2  |  Page : 173-184

Acute toxicity study: fenitrothion induced biochemical changes in male rats

Correspondence Address:
R C Gupta

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Toxicological and biochemical studies of fenitrothion, an organophosphorus insecticide, were conducted in male cats. The oral median lethal dose (LD50) of fenitrothion (98% tech. grade) was calculated to be 365 (251.7-529.2) mg/kg body weight.The oral administration of 75% of LD50 of fenitrothion produced marked toxicity signs characterstic of anti-cholinesterase poisoning during 0.5-3.0 h. and at this time there were also marked alterations in the activities of various enzymes in different tissues. After 1 h of fenitrothion administration, the cholinesterase (ChE) activity was appreciably inhibited in brain, heart and blood and remained markedly inhibited up to 24 h. The maximal increase in the levels of adenosinetriphosphate phosphohydrolase (ATPase), aspartate-aminotransferase, alanine-aminotransferase, alkaline phosphatase and acid-phosphatase in brain, liver, kidney and testes was observed at 12 h. The activities of these enzymes except ChE returned to near control values at 24 h. Plasma levels of aminotransferases and acid phosphatase also showed the similar pattern of the change.The results indicate that the observed changes in the levels of various enzymes in tissues may be due to physiological or pathological alterations induced by fenitrothion and may contribute significantly to their elevated levels in plasma.


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