IPSIndian Journal of Pharmacology
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 RESEARCH PAPER
Year : 1981  |  Volume : 13  |  Issue : 2  |  Page : 167-171

Heterogeneity of beta-adrenoceptors of rabbit intestine



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G Jagadeesh


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The beta-adrenoceptors of rabbit jejunum were investigated for their homogeneity using (-) epinephrine (E), (-)-norepinephrine (NE) and (-)-isoproterenol (IP) as the agonists. The relative order of activity for the beta-receptor sites was found to be IP>NE>E (6.23 : 1.0: 0.48). In the presence of phentolamine (2x 10-6M), bunolol yielded two different pA2 values, 6.1 with E and NE, and 7.9 with IP. However, the regression slopes of Arunlakshana-Schild plots of the three agonists in the presence of bunolol were similar.The results indicate the possibility of the existence of two types of closely related beta adrenergic receptors.






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