IPSIndian Journal of Pharmacology
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 RESEARCH PAPER
Year : 1981  |  Volume : 13  |  Issue : 2  |  Page : 147-152

Muscarinic vasoconstriction of mesenteric blood vessels of frog (Rana Tigrina)



Correspondence Address:
S S Gambhir


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Effect of four choline esters - acetylcholine, carbachol, methacholine and betanechol were studied on perfused mesenteric vascular system of Rana tigrina. These choline esters produced vasoconstrictor responses which were. selectively blocked by very small doses of atropine.Pentolinium and dihydroergotamine partly antagonised the effects of these esters as well as that of barium chloride suggesting nonspecific effect. The results suggest the presence of muscarinic vasoconstrictor receptors in the mesenteric blood vessels of the frog similar to those described in the systemic vasculature of frog (Gambhir and Das, 1978a).






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