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Year : 1981  |  Volume : 13  |  Issue : 2  |  Page : 137-145

Disposition of norepinephrine in the isolated caecorectum preparation of chick

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RCP Singh

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. Disposition of (-) notepinephrine (NE) in the isolated caecorectal preparation of chick was studiedby recording cumulative dose response curves with (-) NE alone and in the presence of specific inhibitor of the mechanisms of amine inactivation and by using oil immersion technique. Relaxant effect of NE (10-5M) on caecorectum of chick contracted with carbachol was potentiated by about 43% with cocaine (3x 10-5M), 23% with iproniazid (10-4M) and 17% with tropolone (10-4M). The results of oil immersion technique indicated that "t50" was increased almost similarly after inhibition of uptake process, monoamine oxidase (MAO) or catechol-O methyl transferase (COMT). The results suggest that neuronal uptake was as important as the role payed by both COMT and MAO taken together.This is in contrast to that reported in mammalian tissues where the uptake process contributes mainly in the disposition of NE.


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