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Year : 1980  |  Volume : 12  |  Issue : 4  |  Page : 247-252

A study on the penicillamine induced gastric ulceration in the rat

Correspondence Address:
B Gupta

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Source of Support: None, Conflict of Interest: None

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. Penicillamine. which is being used as an anti-inflammatory agent for the treatment of rheumatoid arthritis was found to be a potential ulcerogenic agent, as feeding the rats with penicillamine daily for six consecutive days (7.5 and 15.0 mg/kg/day) induced significant gastric ulceration. The induced ulcers could be attributed to the increased acidity of gastric juice. Histaminergic (H1 and H2) receptors appeared to be involved in the penicillamine induced ulcerations in rats.


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