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Year : 1980  |  Volume : 12  |  Issue : 3  |  Page : 149-156

The effect of methamphetamine and diazepam on short-term memory in man

Correspondence Address:
FSK Barar

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Source of Support: None, Conflict of Interest: None

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. A double-blind, placebo-controlled, cross-over study of the effects of methamphetamine and diazepam an short-term memory (STM) was undertaken in 30 healthy volunteers, aged 17 to 44 years. 'Two doses of 5 and 7 mg i.m of each drug were given. After adequate training, eight fixed digit-span strings (one digit/sec) from a prerecorded magnetic tape were presented to the subject, and the number of errors committed at different recall intervals (1,2,4,8,16 and 32 sec) was taken as an index of STM. To avoid rehearsal effect, the longer than one second recall intervals were occupied by a letter shadowing task. Methamphetamine 5 mg did not affect the number of errors (P> 0.6); whereas, with the higher dose (7 mg) it increased errors significantly (P<0.01). Diarepam had no significant effects on error rates at either dose level.


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