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Year : 1980  |  Volume : 12  |  Issue : 2  |  Page : 93-100

Role of mucosubstances in the genesis of stress ulceration produced by electroshock and Exhaustive swimming in albino rats

Correspondence Address:
P K Debnath

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. The present study was planned to evaluate the mechanism of acute and chronic stress ulceration on pylorus ligated rats and to correlate the aggressive acid-peptic factor and defensive mucosubstance. Inbred female albino rats weighing 100120 g and aged 90˝ 5 days were exposed to either electroshock in grid box at 100 volts (1.2 ms, 72/min, 30 min) or swiming at constant temperature (33(1°C). In chronic groups, exposure to stress continued daily for 21 days. Four hour gastric juice was collected in pylorus ligated rats. Gastric juice volume, acid, pepsin, chloride, mucoprotein and mucoproteoses were estimated along with ulcer index. In addition to gastric function, body weight changes, tissue glycogen (liver, ventricle, skeletal muscle, stomach) and adrenal ascorbic acid levels were also estimated to determine the level of stress. On chronic exposure to electroshock or swimming irrespective of increaseor decrease of gastric juice volume and acidity, there was significant decrease of mucoprotein and mucoproteoses along with increased ulcer index. The results indicated that decrease of mucosubstances in the gastric secretion on exposure to stress plays an important role for the development of lesions in the stomach.


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