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Year : 1980  |  Volume : 12  |  Issue : 2  |  Page : 85-91

Sphaeroides oblongus: cardiovascular and respiratory effects

Correspondence Address:
Sanyal Bratati

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Source of Support: None, Conflict of Interest: None

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. A toxic principle (FT) isolated from Sphaeroides oblongus, a poisonous fish, showed dose-dependent (25-800 'g/kg) decreasein cardiac rate and blood pressure accompanied by respiratory depression including transient apnoeic phases in urethane-anaesthetized cat preparations. A peripheral mechanism of action comprising blockade of sympathetic (vasomotor) axonal conductiion, a transient myocardial depression and partial direct musculotropic effect is suggested to be responsible for the bradycardia, hypotension and respiratory depression.


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