| RESEARCH PAPER |
|
| Year : 1980 | Volume
: 12
| Issue : 2 | Page : 85-91 |
Sphaeroides oblongus: cardiovascular and respiratory effects
Sanyal Bratati, BB Patra, BP Mukherjee, S Ganguli
Correspondence Address:
Sanyal Bratati
 Source of Support: None, Conflict of Interest: None  | Check |
.
A toxic principle (FT) isolated from Sphaeroides oblongus, a poisonous fish, showed dose-dependent (25-800 'g/kg) decreasein cardiac rate and blood pressure accompanied by respiratory depression including transient apnoeic phases in urethane-anaesthetized cat preparations. A peripheral mechanism of action comprising blockade of sympathetic (vasomotor) axonal conductiion, a transient myocardial depression and partial direct musculotropic effect is suggested to be responsible for the bradycardia, hypotension and respiratory depression.
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