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Year : 1980  |  Volume : 12  |  Issue : 2  |  Page : 79-84

Mechanism of action of clonidine on body temperature

Correspondence Address:
P N Saxena

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Source of Support: None, Conflict of Interest: None

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. The effect of clonidine hydrochloride has been studied in unanaesthetized albino rats, cats, dogs, guineapigs, pigeons and albino rabbits. A lateral ventricle was chronically cannulated for making intraventricular injections. Clonidine provoked a fall in body temperature by its central action. The rabbit was the least sensitive. It is suggested that the hypothermic effect is mediated through activation of central (-adrenoceptors and it exhibits, like noradrenaline, species dependence and is blocked by phenoxybenzamine in the rat and the cat. Behavioural manifestations of sympathetic stimulation, emesis, chewing, sedation etc. also accompany intraventricular injections of clonidine. The effect of noradrenaline in the rabbit is an excitatory one, that is, a rise in body temperature. Clonidine, which is believed to mimic the depressant effects of central ( -adrenoceptor activation, does not produce this effect of noradrenaline in the rabbit.


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