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Year : 1980  |  Volume : 12  |  Issue : 2  |  Page : 133-136

A study on the acute toxicity and cholinesterase inhibitory activity of O,O-dimethyl-O-(3-Methyl-4-nitrophenyl) phosphorothioate (sumithion) in young and adult rats

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Gowda Honne

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. Influence of age on the acute toxicity of Sumithion was studied by determining the LD50 values in young and adult rats. LD50 with fiducial limits were found to be 525 mg/kg (257.5-787.7) and 748.7 mg/kg (549.8-950.1) in young and adult rats respectively. Young rats were more susceptible than adult ones. Study on the duration of cholinesterase enzyme inhibitory activity of sumithion at 500 mg/kg given orallty in rats indicated complete inhibition of the enzyme activity at 16th hour which persisted till 8th day. Regeneration of the enzyme activity started by 10th day which tended to increase further.


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