IPSIndian Journal of Pharmacology
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Year : 1980  |  Volume : 12  |  Issue : 2  |  Page : 129-131

Safety of vasicine hydrochloride in human volunteers

Correspondence Address:
R L Wakhloo

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Source of Support: None, Conflict of Interest: None

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. Pharmacological, animal toxicity, pharmacokinetic, formulation and stability studies carried out and reported from this Institute in recent years indicated that vasicine, the alkaloid of Adhotoda vasica holds promise for its use as an oxytocic/abortifacient in therapeutics. This report covers the investigations on its clinical pharmacology carried out on 24 human volunteers with 0.5-16 mg dose of vasicine injected iv. in 500 ml saline in 3 hours with the objective of determining any acute human toxicity, tolerance, pharmacological action, any untoward effect and safe dosage range. Vasicine tried upto 16 mg dose on the hospital in-patients on 2nd to 8th day of normal puerperium was well tolerated and showed no undesirable effect in clinical observations, haematological and biochemical investigations and kidney and liver function tests carried out before, during and after vasicine treatment. However, uterus became firm and contracted after vasicine treatment which indicated its effectiveness as an oxytocic.


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