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Year : 1980  |  Volume : 12  |  Issue : 2  |  Page : 113-118

Interaction of some antimicrobial agents with oestrogen in rats

Correspondence Address:
M Thulasimany

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Source of Support: None, Conflict of Interest: None

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. The effect of oral pretreatment of some antimicrobial agents was studied on the uterotropic response of immature female rats to a single oral dose of ethinyl oestradiol. Pretreatment with ampicillin, neomycin, metronidazole or pan-amino salicylic acid significantly enhanced the uterotropic response of ethinyl oestradiol. In addition, treatment with ampicillin, neomycin or metronidazole alone significantly increased the uterine wet weight of control rats. However, none of these agents produced conification of the vaginal smear of ovariectomized adult rats. Phenoxymethylpenicillin, tetracycline, rifampicin, chloroquine and streptomycin did not produce any significant change either on the uterotropic response of ethinyl oestradiol or on the uterine weight of control rats.


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