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Year : 1980  |  Volume : 12  |  Issue : 2  |  Page : 109-112

Effect of 1-histidine pretreatment on the duration of pentobarbitone sleep in mice

Correspondence Address:
V V Joshi

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Source of Support: None, Conflict of Interest: None

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. Pretreatment with L-histidine, precursor of histamine, not only prolonged pentobarbitone sleeping time but also induced sleep in mice treated with a subhypnotic dose of pentobarbitone. These effects of L-histidine were effectively antagonised by prior administration of chlorcyclizine, a H1-receptor blocker. Possible mechanism involved in the potentiating effect of L-histidine on pentobarbitone hypnosis has been discussed.


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