| RESEARCH PAPER
|Year : 1980 | Volume
| Issue : 2 | Page : 109-112
Effect of 1-histidine pretreatment on the duration of pentobarbitone sleep in mice
VV Joshi, JJ Balsara, AG Chandorkar
Pretreatment with L-histidine, precursor of histamine, not only prolonged pentobarbitone sleeping time but also induced sleep in mice treated with a subhypnotic dose of pentobarbitone. These effects of L-histidine were effectively antagonised by prior administration of chlorcyclizine, a H1-receptor blocker. Possible mechanism involved in the potentiating effect of L-histidine on pentobarbitone hypnosis has been discussed.
V V Joshi
Source of Support: None, Conflict of Interest: None