| RESEARCH PAPER |
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| Year : 1980 | Volume
: 12
| Issue : 2 | Page : 109-112 |
Effect of 1-histidine pretreatment on the duration of pentobarbitone sleep in mice
VV Joshi, JJ Balsara, AG Chandorkar
Correspondence Address:
V V Joshi
 Source of Support: None, Conflict of Interest: None  | Check |
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Pretreatment with L-histidine, precursor of histamine, not only prolonged pentobarbitone sleeping time but also induced sleep in mice treated with a subhypnotic dose of pentobarbitone. These effects of L-histidine were effectively antagonised by prior administration of chlorcyclizine, a H1-receptor blocker. Possible mechanism involved in the potentiating effect of L-histidine on pentobarbitone hypnosis has been discussed.
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