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Year : 1980  |  Volume : 12  |  Issue : 2  |  Page : 101-108

Role of adrenoceptor stimulants and blockers in the production of pulmonary edema in mice

Correspondence Address:
N Prakash

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Source of Support: None, Conflict of Interest: None

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. The present study reveals that apart from adrenaline, the alpha adrenoceptor stimulants noradrenaline and phenylephrine are able to induce pulmonary edema in mice. The ineffectiveness of the alpha adrenoceptor blocker tolazoline in preventing adrenaline induced pulmonary edema and a slight protection by it in noradrenaline and phenylephrine induced pulmonary edema may be due to its less effective alpha blocking property and to its transient action.The involvement of beta adrenoceptor in production of pulmonary edema is ruled out since a powerful beta adrenoceptor stimulant isoprenaline has not been able to induce pulmonary edema. The protective effect of beta blocker propranolol in pulmonary edema induced by adrenoceptor stimulants may be due to its action other than beta blocking property namely local anesthetic action. This hypothesis is supported by the fact that i.v. injection of local anesthetics was found to protect against adrenaline induced pulmonary edema by other workers.


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