| CONFERENCE ABSTRACTS |
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| Year : 1980 | Volume
: 12
| Issue : 1 | Page : 31-65 |
Proceedings of the Indian Pharmacological Society XII Annual Conference, December 29-31, 1979, Abstracts
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One gram of sodium tolbutamide was administered orally to twenty-five patients with hepatic cirrhosis and five normal subjects and its serial plasma levels were measured both before and after phenobarbital pretreatment. Phenobarbital administration reduced the enhanced half life (t1/2) of tolbutamide in nonsmokers with hepatic cirrhosis but no significant alteration was produced in smokers with hepatic cirrhosis.
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