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Year : 1980  |  Volume : 12  |  Issue : 1  |  Page : 31-65

Proceedings of the Indian Pharmacological Society XII Annual Conference, December 29-31, 1979, Abstracts

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. One gram of sodium tolbutamide was administered orally to twenty-five patients with hepatic cirrhosis and five normal subjects and its serial plasma levels were measured both before and after phenobarbital pretreatment. Phenobarbital administration reduced the enhanced half life (t1/2) of tolbutamide in nonsmokers with hepatic cirrhosis but no significant alteration was produced in smokers with hepatic cirrhosis.


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