| BOOK REVIEW
|Year : 1979 | Volume
| Issue : 4 | Page : 307
B.N.Ghosh s Text Book of Pharmacology and Therapeutics
Pretreatment with L-histidine, precursor of histamine, was found to potentiate haloperido1 induced catalepsy and to antagonise methamphetamine stereotypy while pretreatment with chlorcyclizine, a H1-receptor blocker, was found to antagonise haloperidol catalepsy and to potentiate methamphetamine stereotypy: Further, chlorcyclizine was found to antagonise the potentiating effect of L-histidine on haloparidol catalepsy and also the inhibitory effect of L histidine on methamphetamine stereotypy. Our results indicate that the central histaminergic system by exerting a modulatory influence on the striatal dopaminergic system may influence the functioning of the extrapyramidal motor system.
S S Bhattacharya
Source of Support: None, Conflict of Interest: None