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Year : 1979  |  Volume : 11  |  Issue : 4  |  Page : 301-305

Toxicologic studies on Kalanchoe integra ľan indigenous plant : Acute toxicity study

Correspondence Address:
R K Varma

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Source of Support: None, Conflict of Interest: None

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. Toxicity of leaves of K. integra was studied in different animals. The aqueous extract was found to be the most toxic. The 24 how LD50 of the leaf extract was 230 and 560 mg/kg, i.p. in mice and rats, respectively. Since the extract showed delayed toxicity in mice, LD50 based cm 48 and 72 hours mortality data were also calculated.The extract was found to be non-poisonous orally in doses upto 2 g/kg in mice and rats.The toxicity of the extract among the different species of animals was in the following descending order: rabbits>dogs> buffalo calves>mice>rats>sheep. The death in mice, rats, rabbits and sheep was preceded by anoxic convulsions, gasping and coma while the dogs and buffalo calves died in the state of central depression.


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