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 RESEARCH PAPER
Year : 1979  |  Volume : 11  |  Issue : 4  |  Page : 287-292

Effect of O,O-dimethyl-O-(3-methyl-4-nitrophenyl) phosphorothioate (Sumithion) on Reproductive performance in rats and oestrogenic activity in mice



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. The effect of Sumithion, an organophosphorus insecticide, on reproductive performance of laboratory animals was studied. Adult female rats were taken for studies on reproductive performance and the vaginal smears were examined by maintaining them on basal ration and on 200 ppm dietary level of Sumithion to find out the difference if any, in oestrus cycle. The animals were then mated with males maintained similarly on the experimental ration. Observations were made for pregnancy, gestation, litter size, abortion and compared with controls. Vaginal smear studies did not reveal any change in the regularity of oestrus cycle. Reproduction indices like fertility, gestation. live birth and lactation indices were not affected during these studies at this dietary level of Sumithion. Oestrogenic activity was evaluated by the mouse uterine weight method after administer-ing 40 and 80 mg/kg of Sumithion and compared with stilboesterol. Identical uterine weights of the control and Sumithion treated groups and significant increase in stilboesterol groups indicated that Sumithion at dose levels used is devoid of oestrogenic activity and is unlikely to exert any influence on the sexual behaviour.






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