| RESEARCH PAPER |
|
| Year : 1979 | Volume
: 11
| Issue : 4 | Page : 277-281 |
Intracerebroventricular administration of histamine in conscious mice induces catalepsy
MP Muley, JJ Balsara, AG Chandorkar
Correspondence Address:
M P Muley
 Source of Support: None, Conflict of Interest: None  | Check |
.
Histamine (10-80 'g), when injected intracerebroventricularly in conscious mice, was found to induce dose dependent degree of catalepsy. Histamine-induced catalepsy was antagonised by chlorcyclizine, a H1-receptor blocker, while pretreatment with metiamide, a H2-receptor blocker, had no effect on histamine-induced catalepsy. The results indicate that the cataleptic effect of histamine is mediated through activation of H1 receptors.
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