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Year : 1979  |  Volume : 11  |  Issue : 4  |  Page : 273-276

Bioavailability of oleandomycin: A comparison of the phosphate and triacetyl esters

Correspondence Address:
A S Nanivadekar

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Source of Support: None, Conflict of Interest: None

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. In a randomised crossover study on 20 human volunteers, oleandomycin phosphate and triacetyl oleandomycin produced comparable mean serum levels following an oral dose equivalent to 500 mg oleandomycin.The triacetyl ester produced significantly lower level in 4 of the subjects, which could be due to inadequate hydrolysis of the ester in the gut on account of poor esterase activity.


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