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Year : 1979  |  Volume : 11  |  Issue : 4  |  Page : 269-272

Pharmacological characterization of histamine receptors in the guinea pig aorta

Correspondence Address:
S C Verma

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Source of Support: None, Conflict of Interest: None

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. The effects of histamine, 2-(2-pyridylethylamine) (PEA), a specific H,-agonist and 4methyl-histamine a specific H2- agonist were studied on the isolated aortic strips of guineapig. Histamine and PEA produced dose related contractions of guineapig aortic strips which were inhibited competitively by mepyramine (1 x 10-5M) an H1-receptor antagonist; whereas burimamide the H2-receptor antagonist had no significant effects on the histamine or PEA induced contractions. 4-Methyl histamine failed to produce any significant effect on the guineapig aortic strips. Pretreatment with reserpine (5 mg/kg ip., 24 h before sacrifice) did not produce any significant change in the dose-response curve of histamine. These findings suggest that histamine has direct effects on guineapig aorta and it appears that a predominant distribution of H1-receptor occurs in this tissue.


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