| RESEARCH PAPER
|Year : 1979 | Volume
| Issue : 4 | Page : 265-268
Investigations into the positive inotropic effect of ST 600 [2-(5-fluoro-O-toluidine)-2-imidazoline hydrochloride] on isolated hearts
A Veeranjaneyulu, SC Verma
ST 600 [2-(5 fluoro-O-toluidine)-2 imidazoline hydrochloride] in doses 2.5 to 40 'g injected into the isolated perfused guineapig heart caused an increase in contractile force. The effects of ST 600 were blocked by metiamide (3x 10-5M). Mepyramine or reserpine treatment (5mg/kg i.p.; 24 h prior to the experiment) did not influence the contractile effects of ST 600. Clonidine and ST 600 both produced parallel dose-response curves, which were competitively antagonized by H1-receptor antagonists burimamide and metiamide respectively. It is suggested that the inotropic action of ST 600 is due to stimulation of histamine H2-receptors.
Source of Support: None, Conflict of Interest: None