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Year : 1979  |  Volume : 11  |  Issue : 4  |  Page : 257-264

Influence of zinc sulphate on steroid depressed wound healing

Correspondence Address:
P V Diwan

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Source of Support: None, Conflict of Interest: None

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. The value of supplemental zinc in wound healing in nutritionally normal individuals has remained controversial. Possibly, zinc might have differential action on optimally and sub-optimally healing wounds. This hypothesis was experimentally verified by monitoring wound contraction, epithelization in excised wounds (rabbits); tensile strength in healing incision-wounds (guineapigs) and weights of cotton pellet granuloma (rats). Wound/pellet baring animals were divided into control (saline OS ml i.p.) and steroid (dexamethasone 0.17-0.33 mg/kg/day i. m.) groups. Some animals in each group received zinc sulphate topically (1% ointment) or parenterally (25-100 mg/kg i.p.). In control animals with optimal healing zinc sulphate bad no influence. On the other hand, the steroid induced depression of healing was significanlty (P<0.001 to <0.05) prevented by zinc sulphate treatment.


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