| SHORT COMMUNICATION
|Year : 1979 | Volume
| Issue : 3 | Page : 233-237
A note on the need for pyrogen test in aminophylline injection
SC Gupta, GS Lal, PR Pabrai
The test for freedom from pyrogens in aminophylline injection is not prescribed in any pharmacopoeia probably in the belief that theophylline contained in aminophylline injection, being a xanthine derivative, may interfere with the pyrogen test because of its antipyretic property. This investigation reveals that doses of aminophylline as high as 25 mg/kg do not interfere with the official test in rabbits and that when the sample was contaminated with a pyrogenic material, a rise in temperature was observed.The inclusion of the test for freedom from pyrogens in aminophylline injection in the official compendia is therefore recommended.
S C Gupta
Source of Support: None, Conflict of Interest: None