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Year : 1979  |  Volume : 11  |  Issue : 3  |  Page : 233-237

A note on the need for pyrogen test in aminophylline injection

Correspondence Address:
S C Gupta

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Source of Support: None, Conflict of Interest: None

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. The test for freedom from pyrogens in aminophylline injection is not prescribed in any pharmacopoeia probably in the belief that theophylline contained in aminophylline injection, being a xanthine derivative, may interfere with the pyrogen test because of its antipyretic property. This investigation reveals that doses of aminophylline as high as 25 mg/kg do not interfere with the official test in rabbits and that when the sample was contaminated with a pyrogenic material, a rise in temperature was observed.The inclusion of the test for freedom from pyrogens in aminophylline injection in the official compendia is therefore recommended.


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