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Year : 1979  |  Volume : 11  |  Issue : 3  |  Page : 229-232

Evaluation of anti-allergic activity of Tylophora indica using rat lung perfusion

Correspondence Address:
S S Nayampalli

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Source of Support: None, Conflict of Interest: None

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. The anti-allergic effect of Tylophora indica was compared with that of disodium cromoglycate on perfused rat lung in sensitized rats by observing the changes in the volume of the perfusate per minute. The rats were semitized with Freund's adjuvant and bovine albumin 0.05 ml each given intraperitoneally. Aqueous extract of Tylophora indica (5% soln.) was administered intraperitoneally (5 mg/kg) 3 days prior to sensitization. The rate of flow increased from 7.65 to 19.55 ml/min (P<0.05). Administration of aqueous extract of Tylophora indica and disodium cromoglycate during perfusion of sensitized rat lung significantly increased the rate of flow.The action of Tylophora indica may be due to direct bronchodilator property and membrane stabilising and immuno-suppressive effects.


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