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Year : 1979  |  Volume : 11  |  Issue : 3  |  Page : 219-228

Evaluation of antihistamine activity of ethamidindole, a new 2-substituted pyrazinopyridoindole

Correspondence Address:
G K Patnaik

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Source of Support: None, Conflict of Interest: None

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. Ethamidindok a new Z-substituted pyrazinopyridoindole, showed antihistaminic activity in cat, rabbit and guineapig in various in vivo and in vitro test models. The antagonism was competitive like that of mepyramine. It also inhibited the antigen induced contraction of the intestine of sensitized guineapigs. Both the peripheral and central effects of histamine, mediated via H1-receptors were antagonised by ethamidindole. The compound was well absorbed from the intestinal tract of cats. Ethamidindok was, however, less potent than mepyramine.


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