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Year : 1979  |  Volume : 11  |  Issue : 3  |  Page : 209-217

Effect of ammonium chloride and sodium bicarbonate on pharmacokinetics of three sulphonamides

Correspondence Address:
P P Shidore

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Source of Support: None, Conflict of Interest: None

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. Present work was undertaken to study the effects of sodium bicarbonate and ammonium chloride on absorption and elimination kinetics of three sulfonamides. Alteration in urinary pH ranging from 5 to 8 did not show statistically significant Difference in total urinary excretion of sulfonamides during six hours of the study with different treatments. Apparent higher clearance of sulfonamides was observed during initial period of the study. It was concluded from the results that slow rate of absorption of sulfonamides with ammonium chloride treatment might be contributing to some extent to slow clearance of sulfonamides in acidic urine during initial period of the study.


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